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  • Title: Stat5a is essential for the proliferation and survival of murine mast cells.
    Author: Ikeda K, Nakajima H, Suzuki K, Watanabe N, Kagami S, Iwamoto I.
    Journal: Int Arch Allergy Immunol; 2005; 137 Suppl 1():45-50. PubMed ID: 15947484.
    Abstract:
    The regulatory role of signal transducer and activator of transcription (Stat) 5a in the proliferation and survival of mast cells was determined using Stat5a-deficient (Stat5a(-/-)) mice. First, although the mast cells in Stat5a(-/-) mice were morphologically indistinguishable from those in wild-type (WT) mice, the number of peritoneal mast cells was significantly decreased in Stat5a(-/-) mice as compared with that in WT mice. Furthermore, the interleukin-3 (IL-3)-dependent development of bone marrow-derived mast cells (BMMCs) was markedly decreased in Stat5a(-/-) mice. Second, IL-3-induced but not stem cell factor (SCF)-induced proliferation of BMMCs was significantly diminished in Stat5a(-/-) mice as compared with that in WT mice. Moreover, survival rates of both peritoneal mast cells and BMMCs were significantly decreased with increased apoptotic cells in Stat5a(-/-) mice as compared with those in WT mice. Finally, mRNA of Bcl-x(L) was induced after IL-3 stimulation in WT BMMCs but not in Stat5a(-/-) BMMCs, which may account for the accelerated apoptosis in Stat5a(-/-) mast cells. These results indicate that Stat5a plays an important role in mast cell development, proliferation, and survival.
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