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Title: [Detection of CCAAT/enhancer binding protein alpha gene mutations in acute myeloid leukemia]. Author: Zhao JM, Wang HW, Xu ZF, Zhu L, Bai B, Ge XY. Journal: Zhonghua Xue Ye Xue Za Zhi; 2005 May; 26(5):299-302. PubMed ID: 15949295. Abstract: OBJECTIVE: To explore the relationship between CCAAT/enhancer binding protein alpha (C/EBPalpha) gene mutations and the development of acute myeloid leukemia (AML). METHODS: The whole coding region of C/EBPalpha gene were screened in 48 cases of AML and 11 normal subjects by PCR-single strand conformation polymorphism (PCR-SSCP) and sequencing. RESULTS: C/EBPalpha mutations were detected in 5 of 48 AML patients. Four duplications and 1 deletion were confirmed by DNA sequencing. All of those are newly identified mutations. CONCLUSIONS: Different mutation types of C/EBPalpha gene exist in a small number of patients with AML and might be related to the pathogenesis of some leukemias.[Abstract] [Full Text] [Related] [New Search]