These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effect of granulocyte-macrophage colony stimulating factor on the repair of vessel intima damaged by balloon].
    Author: Zhang XH, Ma XJ, Zhao T.
    Journal: Zhonghua Yi Xue Za Zhi; 2005 Mar 09; 85(9):635-7. PubMed ID: 15949364.
    Abstract:
    OBJECTIVE: To observe the effect of granulocyte-macrophage colony stimulating factor (GM-CSF) on the repair of damaged iliac arteries. METHODS: Twenty-four male New Zealand White rabbits were randomized to two equal groups: GM-CSF group receiving subcutaneous injection of GM-CSF (10 microg.kg(-1).d(-1)), and control group receiving subcutaneous injection of normal saline. Seven days later all rabbits underwent insertion and expansion of balloon into the right iliac arteries so as to cause damage. Four weeks after the operation the operated iliac arteries of the GM-CSF group and the left iliac arteries of the control group were collected to undergo pathological examination. The repair and hyperplasia of intima were observed by microscopy and the indices of restenosis were evaluated by computerized planimetry. RESULTS: Histological examination showed that hyperplasia of neogenetic intima was lighter, numbers of vascular smooth muscle cells and fibrous tissue were less, degree of lumen stenosis was slighter, and the endothelium was more integrated in the GM-CSF group in comparison with the control group. Morphometry showed that the lumen area of the GM-CSF group was 1.27 mm(2) +/- 0.31 mm(2), significantly larger than that of the control group (0.92 mm(2) +/- 0.24 mm(2), P < 0.05). The area of neogenetic intima of the GM-CSF group was 0.85 mm(2) +/- 0.34 mm(2), significant smaller than that of the control group (1.18 +/- 0.38, P < 0.05), and the percentage of intimal hyperplasia of the GM-CSF group was 40% +/- 7%; significantly lower than that of the control group (55% +/- 6%, P < 0.05). CONCLUSION: GM-CSF promotes the repair of intima, reduces the new intima formation, and decreases the rate of restenosis.
    [Abstract] [Full Text] [Related] [New Search]