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  • Title: Sex determination: a tale of two Sox genes.
    Author: Koopman P.
    Journal: Trends Genet; 2005 Jul; 21(7):367-70. PubMed ID: 15949865.
    Abstract:
    Vertebrates use many different strategies to determine sex, but the Sox9 gene is a common thread, probably acting as the pivotal gene that controls the male-determining pathway. It now appears that Sox9 is not alone in this role, and that a closely related gene, Sox8, can partly substitute for Sox9. But is this a clever backup strategy to safeguard male development, or a relic of the past?
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