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  • Title: Pathogen recognition with Toll-like receptors.
    Author: Kawai T, Akira S.
    Journal: Curr Opin Immunol; 2005 Aug; 17(4):338-44. PubMed ID: 15950447.
    Abstract:
    The innate immune system is an evolutionarily conserved system of defense against microbial infections. The family of Toll-like receptors is a major class of receptors that sense molecular patterns associated with a broad range of pathogens including bacteria, viruses, fungi and protozoa. Following pathogen recognition, Toll-like receptors initiate intracellular signal transduction that results in the expression of genes involved in inflammation, antiviral responses and maturation of dendritic cells. Individual Toll-like receptors activate common and unique transcription factors through different signaling pathways to drive specific biological responses against microorganisms.
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