These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Pax genes in eye development and evolution.
    Author: Kozmik Z.
    Journal: Curr Opin Genet Dev; 2005 Aug; 15(4):430-8. PubMed ID: 15950457.
    Abstract:
    Animal eyes with widely different anatomical designs have long been thought to arise independently, multiple times during evolution. This view was challenged about a decade ago by the landmark discoveries that Pax6, a highly conserved transcription factor, plays a key role in eye morphogenesis in both flies and mammals. Since then, more evidence has emerged in favour of the redeployment of Pax6 and some other developmental control genes within the genetic program underlying eye formation throughout the animal kingdom. Recent work has indicated that other members of the Pax gene family play a pivotal role in eye morphogenesis. The Eye gone gene regulates eye growth in Drosophila, whereas the PaxB gene is implicated in visual system development in jellyfish, the most basal organism possessing eyes.
    [Abstract] [Full Text] [Related] [New Search]