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  • Title: Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents.
    Author: Tandon VK, Yadav DB, Singh RV, Vaish M, Chaturvedi AK, Shukla PK.
    Journal: Bioorg Med Chem Lett; 2005 Jul 15; 15(14):3463-6. PubMed ID: 15950468.
    Abstract:
    A series of 1,4-naphthoquinone derivatives were synthesized and evaluated for antibacterial and antiviral activities. The structure-activity relationships of these compounds were also studied. The results suggest that compounds 9-22 showed in vitro marked antibacterial activity. Compounds 4c and 7a showed inhibitory effect against RNA dependent RNA polymerase induced poliovirus type 2 infected HeLa cells.
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