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  • Title: Structure-driven HtL: design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity.
    Author: Stocks MJ, Barber S, Ford R, Leroux F, St-Gallay S, Teague S, Xue Y.
    Journal: Bioorg Med Chem Lett; 2005 Jul 15; 15(14):3459-62. PubMed ID: 15950471.
    Abstract:
    The design and synthesis of a new series of c-Jun N-terminal kinase inhibitors are reported. The novel series of substituted amino indazoles were designed based on a combination of hits from high-throughput screening and X-ray crystal structure information of the compounds crystallised into the JNK-1 ATP binding site.
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