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  • Title: Inhibin A and activin A may be used to predict pregnancy outcome in women with recurrent miscarriage.
    Author: Prakash A, Laird S, Tuckerman E, Li TC, Ledger WL.
    Journal: Fertil Steril; 2005 Jun; 83(6):1758-63. PubMed ID: 15950648.
    Abstract:
    OBJECTIVE: To look at the role of inhibin and activin in predicting pregnancy outcome in patients with history of recurrent miscarriage. DESIGN: Observational clinical study. SETTING: Recurrent miscarriage clinic of a tertiary care teaching hospital. PATIENT(S): Patients with history of recurrent miscarriage. INTERVENTION(S): Serial serum inhibin A and activin A concentrations were measured in weeks 5 though 8 of pregnancy. MAIN OUTCOME MEASURE(S): Serum concentrations of inhibin A and activin A levels. RESULT(S): Mean inhibin A concentration at 5 to 6 weeks for women who miscarried and those who had live births was 33 and 51 pg/mL, respectively; activin A at same gestation for the two groups was 534 and 643 pg/mL, respectively. After 2 weeks, mean inhibin A concentration for women who miscarried and those who had live births was 66 and 145 pg/mL, respectively, and activin A was 747 and 1,123 pg/mL, respectively. CONCLUSION(S): It is possible that inhibin A and activin A may be used as markers to predict pregnancies that are likely to miscarry.
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