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  • Title: [Study on the oxidative injury of the vascular endothelial cell affected by PM2.5].
    Author: Dong C, Song WM, Shi YW.
    Journal: Wei Sheng Yan Jiu; 2005 Mar; 34(2):169-71. PubMed ID: 15952654.
    Abstract:
    OBJECTIVE: To study the mechanism of cardiovascular disease affected by PM2.5. METHODS: ECV304 cells were exposed to PM2.5 of different concentration (50, 200 and 400 microg/ml), after 24h, the viability of cells by MTT, SOD and GSH contents in cells and apoptosis of cells determined by flow cytometer were measured. RESULTS: Viability of ECV304 cells declined and mortality of ECV304 cells increased gradually with increase of concentration, GSH contents in cells (mg/g prot) were 20.643 +/- 2.167, 16.774 +/- 2.911 (P < 0.05), 15.658 +/- 3.471 (P < 0.01), and SOD contents in cells (U/mg prot) were 5.878 +/- 0.401, 5.140 +/- 0.448 (P < 0.01), 4.817 +/- 0.451 (P < 0.01) when the concentration of PM2.5 was 50, 200 and 400 microg/ml. CONCLUSION: PM2.5 can cause vascular endothelial cells to die by way of oxidative injury, then induce cardiovascular disease.
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