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  • Title: Getting RIP'd Stunts Your Growth.
    Author: Ceni C, Barker PA.
    Journal: Neuron; 2005 Jun 16; 46(6):839-40. PubMed ID: 15953410.
    Abstract:
    The p75 neurotrophin receptor (p75NTR) collaborates with the Nogo receptor (NgR) and LINGO-1 to activate RhoA in response to myelin-based growth inhibitors such as myelin-associated glycoprotein (MAG). In this issue of Neuron, Domeniconi et al., in a surprising turn, show that MAG induces intramembrane proteolysis (RIP) of p75NTR and find that p75NTR cleavage is required for MAG-induced RhoA activation and growth inhibition.
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