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  • Title: Disruption and restoration of cell-cell junctions in mouse vestibular epithelia following aminoglycoside treatment.
    Author: Kim TS, Nakagawa T, Kitajiri S, Endo T, Takebayashi S, Iguchi F, Kita T, Tamura T, Ito J.
    Journal: Hear Res; 2005 Jul; 205(1-2):201-9. PubMed ID: 15953529.
    Abstract:
    The intracellular junction complexes, which consist of tight junctions (TJ), adherens junctions (AJ), and desmosomes, mediate cell-cell adhesion in epithelial cells. E-cadherin, which is a major component of AJ, plays a role not only in the maintenance of cell-cell junctions, but also in repressing cell proliferation. In this study, we examined changes of E-cadherin expression in mouse vestibular epithelia following local application of neomycin using immunohistochemistry and western blotting, and morphology of cell-cell junctions by transmission electron microscopy (TEM). Immunohistochemistry and western blotting revealed down-expression of E-cadherin and its consecutive recovery. TEM demonstrated temporal disruption of cell-cell junctions. Morphology of cell-cell junctions was more rapidly restored than recovery of E-cadherin expression. Transient disruption of cell-cell junctions and down-expression of E-cadherin is a rational response for the deletion of dying hair cells, and may be associated with a limited capacity for cell proliferations in mammalian vestibular epithelia following their rapid restoration.
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