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  • Title: recA gene expression in a streptomycete is mediated by the unusual C-terminus of RecA protein.
    Author: Ahel I, Mikoc A, Gamulin V.
    Journal: FEMS Microbiol Lett; 2005 Jul 01; 248(1):119-24. PubMed ID: 15953699.
    Abstract:
    Streptomyces RecA proteins are characterized by a conserved, positively charged extension of unknown function appended at their C-termini. To investigate the function of this element, we introduced the Streptomyces rimosus recA gene and its mutant form encoding the protein with a C-terminal deletion into S. rimosus. Both transcript and protein levels were dramatically increased in the strain expressing the truncated gene compared to the strain bearing the wild-type recA, indicating involvement of the characteristic C-terminal extension in regulating the recA expression in Streptomyces. Considering that RecA acts as a major regulator of DNA damage response in bacteria, this mode of regulation is expected to have broader implications and significance that outreaches our current understanding of RecA autoregulation.
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