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  • Title: Oritavancin: a new avenue for resistant Gram-positive bacteria.
    Author: Mercier RC, Hrebickova L.
    Journal: Expert Rev Anti Infect Ther; 2005 Jun; 3(3):325-32. PubMed ID: 15954849.
    Abstract:
    Oritavancin, a new semisynthetic glycopeptide has a spectrum of activity similar to vancomycin, although it exhibits potent antimicrobial activity against vancomycin-resistant staphylococci and enterococci species. It has a long-terminal half-life of 360 h, is highly protein bound and has been dosed once-daily in clinical trials. Oritavancin has been studied in complicated skin and skin structure infections where it was noninferior to the comparator group of vancomycin/cephalexin. Thus far, oritavancin has a favorable side-effect profile and appears promising in the treatment of multidrug resistant Gram-positive bacteria.
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