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  • Title: Proteomic analysis of Gal/GalNAc lectin-associated proteins in Entamoeba histolytica.
    Author: McCoy JJ, Mann BJ.
    Journal: Exp Parasitol; 2005 Jul; 110(3):220-5. PubMed ID: 15955316.
    Abstract:
    Contact-dependent killing and phagocytosis of target cells by Entamoeba histolytica trophozoites is mediated by the galactose (Gal) and N-acetyl-d-galactosamine (GalNAc)-inhibitable lectin. Previous work has suggested that this lectin functions as part of a signal transduction complex. To identify proteins that might be part of this complex, amebic trophozoites were bound to GalNAc-BSA-labeled magnetic beads and lysed. Bound proteins were eluted from the beads and analyzed by tandem mass spectrometry. Along with the Gal/GalNAc lectin subunits, several cytoskeletal proteins, potential signaling proteins, and a novel transmembrane protein, consistently purified with the GalNAc-BSA beads.
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