These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of subtotal fasting on plasmatic coagulation, fibrinolytic status and platelet activation: a controlled pilot study in healthy subjects.
    Author: Huber R, Nauck M, Basler N, Haas B, Mattern M, Lüdtke R, Peter K.
    Journal: Nutr Metab Cardiovasc Dis; 2005 Jun; 15(3):212-8. PubMed ID: 15955470.
    Abstract:
    BACKGROUND AND AIM: There is considerable controversy as to whether fasting can be recommended to patients with cardiovascular disease. The objective of this study was to determine whether a well-known method of 1-week subtotal fasting affects hemostasis in healthy subjects. METHODS AND RESULTS: Analyses were carried out before, four times during and 3 days after fasting in 12 fasting subjects (< 300 kcal/day, only from carbohydrates) (group 1), and 8 control subjects (group 2). Plasmatic coagulation (prothrombin time, partial thromboplastin time, p < or = 0.001) and fibrinolysis (plasminogen, plasmin-antiplasmin-complex, p < 0.05) increased during fasting but remained within the normal limits. While the platelet count was similar in both groups, platelet sensitivity to stimulators was reduced in group 1 (P-selectin and activated GP IIb/IIIa on ADP-stimulated platelets, p < or = 0.01). Furthermore, soluble P-selectin (p < or = 0.01) and C-reactive protein were decreased in comparison to group 2 (p < or = 0.05). CONCLUSIONS: Hemostasis and inflammation parameters during 1-week subtotal fasting do not imply an increase in cardiovascular risk.
    [Abstract] [Full Text] [Related] [New Search]