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  • Title: Combining the case-control methodology with the small size transmission/disequilibrium test for multiallelic markers.
    Author: Guo W, Fung WK.
    Journal: Eur J Hum Genet; 2005 Sep; 13(9):1007-12. PubMed ID: 15957000.
    Abstract:
    Case-control studies compare marker-allele distributions in affected and unaffected individuals, and significant results may be due to linkage but can also simply reflect population structure. To test for linkage after obtaining a significant case-control finding, within-family analysis can be performed. In a transmission/disequilibrium test (TDT), genotypes of cases are compared to those of their parents to explore whether a specific allele, or marker, at a locus of interest is transmitted to a greater degree than Mendelian inheritance would warrant. For multiallelic markers, several authors have proposed extensions to the TDT. In this article, we propose a TDT test, utilizing the available information of a case-control study in the grouping of alleles for multiallelic markers, and thereby increase the statistical power of a TDT test with a small sample size.
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