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  • Title: Structure and anti-HIV activity of micrandilactones B and C, new nortriterpenoids possessing a unique skeleton from Schisandra micrantha.
    Author: Li RT, Han QB, Zheng YT, Wang RR, Yang LM, Lu Y, Sang SQ, Zheng QT, Zhao QS, Sun HD.
    Journal: Chem Commun (Camb); 2005 Jun 21; (23):2936-8. PubMed ID: 15957031.
    Abstract:
    Two new highly oxygenated nortriterpenoids with a unique norcycloartane skeleton, micrandilactones B and C, were isolated from Schisandra micrantha; micrandilactone C exhibited an EC50 value of 7.71 microg/mL (SI > 25.94) against HIV-1 replication with minimal cytotoxicity, and the potent anti-HIV-1 activity and unique structural features of make it a promising lead for therapeutic development of a new generation of anti-HIV drug.
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