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  • Title: Effective synthesis of 1beta-acyl glucuronides by selective acylation.
    Author: Perrie JA, Harding JR, Holt DW, Johnston A, Meath P, Stachulski AV.
    Journal: Org Lett; 2005 Jun 23; 7(13):2591-4. PubMed ID: 15957898.
    Abstract:
    [reaction: see text] Acyl glucuronides are vital metabolites for many carboxylic acid containing drugs. We report an efficient new method for the chemical synthesis of these molecules by selective 1beta-acylation of allyl glucuronate with carboxylic acids catalyzed by HATU and then mild deprotection through treatment with Pd(PPh(3))(4) and morpholine. The method is effective for a range of aryl and alkyl carboxylic acids, including important drugs.
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