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  • Title: Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard?
    Author: Levin I, Gamzu R, Pauzner D, Rogowski O, Shapira I, Maslovitz S, Almog B.
    Journal: BJOG; 2005 Jul; 112(7):952-5. PubMed ID: 15957998.
    Abstract:
    OBJECTIVE: Elevated levels of C-reactive protein (CRP) were found recently to be a crucial marker for cardiovascular disease. This protein might have a role in endothelial cell activation, vascular damage and a thrombotic tendency. We sought to determine whether concentrations of CRP are altered in women with controlled ovarian hyperstimulation (COH) or hyperstimulation syndrome (OHSS). DESIGN: A prospective cohort study. SETTING: The gynecology department and IVF unit of the Lis maternity hospital. POPULATION: Twenty women with OHSS, 20 women undergoing COH and 20 women who participated as controls were included in the study. METHODS: Venous blood was withdrawn for analysis of high sensitive C-reactive protein (hs-CRP) using the Boering BN-II nephelometer. MAIN OUTCOME MEASURES: hs-CRP levels were determined. RESULTS: There was a significant (P < 0.05) difference in the hs-CRP concentrations in women with OHSS compared with women with COH and controls. The respective values for hs-CRP were 19.0 [4.0], 7.0 [1.7] and 4.6 [1.1] mg/L. CONCLUSIONS: Women with OHSS have elevated concentrations of hs-CRP. This finding, previously believed to merely represent an acute phase response, may actually represent a yet unrecognised pathophysiological factor of this syndrome and pave the way for new investigational directions of this potentially hazardous condition.
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