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  • Title: [The role of gastroesophageal reflux in malignization of post-burn and peptic esophageal strictures].
    Author: Allakhverdian AS, Mazurin VS, Kazantseva IA, Isakov VA, Titov AG, Morozov SV, Zafirov AG.
    Journal: Vestn Ross Akad Med Nauk; 2005; (5):20-4. PubMed ID: 15960199.
    Abstract:
    The subjects of the study were 221 patients with cicatrical esophageal strictures. 62 (28.5%) patients had peptic strictures, and 159 (71.9%)--post-burn strictures. 67 (30.3%) patients underwent esophageal resection with one-stage intrapleural esophagoplasty with the stomach, 152 (68.8%) patients--gullet bougienage in combination with surgical intervention or as an only treatment. The study revealed 8 cases of squamous cell carcinoma in patients with post-burn strictures, and 3 cases of squamous cell carcinoma in patients with peptic strictures. In 2 cases the researchers found early stage of esophageal cancer (verrucose carcinoma)--in 1 patient with post-burn stricture and 1 patient with peptic stricture. The results suggest an important role of chronic gastroesophageal reflux in the oncogenesis of esophageal squamous cell carcinoma in patients with post-burn and peptic strictures.
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