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Title: Getting downstream without a Raft. Author: Lin J, Shaw AS. Journal: Cell; 2005 Jun 17; 121(6):815-6. PubMed ID: 15960968. Abstract: The role of plasma-membrane microdomains in the organization of signaling proteins has been a controversial topic in T cell signaling. In this issue of Cell, use of single-molecule fluorescence suggests that protein-protein interactions, not detergent insolubility, regulate the assembly of signaling complexes in the plasma membrane.[Abstract] [Full Text] [Related] [New Search]