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  • Title: Development of activity standard for 90 Y microspheres.
    Author: Mo L, Avci B, James D, Simpson B, Van Wyngaardt WM, Cessna JT, Baldock C, Australian Nuclear Science Organization.
    Journal: Appl Radiat Isot; 2005 Aug; 63(2):193-9. PubMed ID: 15963429.
    Abstract:
    (90)Y microspheres are important therapeutic radiopharmaceuticals used in the treatment of liver cancer through a process known as selective internal radiation therapy. SIR-spheres is a radiopharmaceutical product that is comprised of (90)Y microspheres suspended in sterile, pyrogen-free water for injection into patients. It is necessary to establish for the SIR-spheres production the capability of accurately measuring the activity of this product to a traceable national measurement standard. An activity standard for SIR-spheres was developed from a standard for (90)Y solution, employing a highly quantifiable chemical digestion process. Calibration factors for the manufacturer's ionisation chambers were determined for 1 and 5 ml of the SIR-spheres product placed in Wheaton vials, for both 34% and 44% of (90)Y microsphere concentration.
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