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  • Title: Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation.
    Author: Teyssier C, Ma H, Emter R, Kralli A, Stallcup MR.
    Journal: Genes Dev; 2005 Jun 15; 19(12):1466-73. PubMed ID: 15964996.
    Abstract:
    Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha), a tissue-specific and inducible transcriptional coactivator for several nuclear receptors, plays a key role in energy metabolism. We report here that PGC-1alpha coactivator activity is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator. Mutation of three substrate arginines in the C-terminal region of PGC-1alpha abolished the cooperative coactivator function of PGC-1alpha and PRMT1, and compromised the ability of PGC-1alpha to induce endogenous target genes. Finally, endogenous PRMT1 contributes to PGC-1alpha coactivator activity, and to the induction of genes important for mitochondrial biogenesis.
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