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  • Title: A capillary electrophoresis chip with hydrodynamic sample injection for measurements from a continuous sample flow.
    Author: Büttgenbach S, Wilke R.
    Journal: Anal Bioanal Chem; 2005 Nov; 383(5):733-7. PubMed ID: 15965683.
    Abstract:
    A microchip-based capillary electrophoresis device supported by a microfluidic network made of poly(dimethylsiloxane), used for measuring target analytes from a continuous sample flow, is presented. The microsystem was fabricated by means of replica molding in combination with standard microfabrication technologies, resulting in microfluidic components and an electrochemical detector. A new hydrodynamic sample injection procedure is introduced, and the maximum number of consecutive measurements that can be made with a poly(dimethylsiloxane) capillary electrophoresis chip with amperometric detection is investigated with respect to reproducibility. The device features a high degree of functional integration, so the benefits associated with miniaturized analysis systems apply to it.
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