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  • Title: Characterization and quantitation of membrane proteomes using multidimensional MS-based proteomic technologies.
    Author: Blonder J, Conrads TP, Veenstra TD.
    Journal: Expert Rev Proteomics; 2004 Aug; 1(2):153-63. PubMed ID: 15966810.
    Abstract:
    A major goal of proteomics is to develop methods that enable the systematic characterization of every protein within the cell or particular subcellular proteome using a single analytical platform. Although the equivalent has already been achieved in genomics, reaching this goal in proteomics represents a much greater challenge due to the wide dynamic range of protein expression, numerous post-translational modifications and remarkable physicochemical heterogeneity of proteins. A major analytical challenge has involved developing more effective means for proteome-scale investigations of membrane proteins, whose solubility differs drastically from that of cytoplasmic proteins. Fortunately, rapid progress has increased the ability to characterize this critically important class of proteins on a scale analogous to that of aqueous soluble proteins.
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