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  • Title: Synthesis, characterization and biological activity of triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates.
    Author: Tian L, Sun Y, Li H, Zheng X, Cheng Y, Liu X, Qian B.
    Journal: J Inorg Biochem; 2005 Aug; 99(8):1646-52. PubMed ID: 15967504.
    Abstract:
    The triorganotin 2-phenyl-1,2,3-triazole-4-carboxylates, 2-PhC2N3CO2SnR3 (R=C6H5, 1; c-C6H11, 2; C6H5C(CH3)2CH2, 3), have been prepared and characterized by means of elemental analysis, IR and NMR (1H, 13C and 119Sn) spectroscopy. The crystal structures of 1 and 3 have been determined. Compound 1 is polymeric in nature with a trigonal bipyramidal configuration, and compound 3 shows a tetrahedral geometry. Bioassay results have shown that these compounds have good antibacterial and antitumor activity. The activity against three human tumor cell lines (HeLa, CoLo205 and MCF-7) decreased in the order 1>2>3.
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