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  • Title: Concise synthesis and voltammetric studies of dielsiquinone, a cytotoxic azaanthraquinone.
    Author: Brisach-Wittmeyer A, Souna Sido AS, Guilini P, Désaubry L.
    Journal: Bioorg Med Chem Lett; 2005 Aug 01; 15(15):3609-10. PubMed ID: 15967662.
    Abstract:
    We have developed a concise synthesis of dielsiquinone 1, a potent cytotoxic agent related to anthraquinones. Electrochemical studies have shown that dielsiquinone is reduced to a semiquinone radical that does not react with O2 to generate toxic reactive oxygen species. These results strongly suggest that 1 should be less cardiotoxic than anthracyclines used in clinic and may therefore provide the basis for the development of safer anticancer drugs.
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