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  • Title: Antiproliferative hopane and oleanane glycosides from the roots of Glinus lotoides.
    Author: Hamed AI, Piacente S, Autore G, Marzocco S, Pizza C, Oleszek W.
    Journal: Planta Med; 2005 Jun; 71(6):554-60. PubMed ID: 15971128.
    Abstract:
    Three new hopane saponins, lotoidosides A - C (1 - 3), and four new oleanane saponins, lotoidosides D - G (4 - 7), were isolated from the roots of Glinus lotoides L. (Molluginaceae). Their structures were determined by extensive 1D- and 2D-NMR spectroscopy and ESI-MS analysis. The antiproliferative activity of compounds 1 - 7 was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, WEHI-164. Compounds 1 and 3 - 7 showed significant cytotoxicity against the three cancer cell lines with IC50 values ranging from 0.018 to 0.62 microM, while compound 2 exerted a weak activity only against the cell line HEK-293.
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