These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: A biflavonoid from Luxemburgia nobilis as inhibitor of DNA topoisomerases.
    Author: Oliveira MC, de Carvalho MG, Grynberg NF, Brioso PS.
    Journal: Planta Med; 2005 Jun; 71(6):561-3. PubMed ID: 15971129.
    Abstract:
    The biflavonoid 2'',3''-diidroochnaflavone ( 1), isolated from the leaves of Luxemburgia nobilis, was cytotoxic to murine Ehrlich carcinoma (IC50 = 17.2 microM) and human leukemia K562 cells (IC50 = 89.0 microM) in a concentration-dependent manner in 45 h cell culture. The acetyl (1a) and methyl (1b) derivatives of 1 were not cytotoxic to these tumour cells at 67.0 and 82.0 microM concentrations, respectively. Biflavonoid 1 as well 1a inhibit the activity of human DNA topoisomerases I and II-alpha as observed in relaxation and decatenation assays. In addition, we show that 1 is a DNA interacting agent, which causes DNA unwinding in an assay with topoisomerase I. Also, spectrophotometric titration of 1 with DNA resulted in a pronounced hypochromic effect.
    [Abstract] [Full Text] [Related] [New Search]