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  • Title: Sedative and anticonvulsant effects of hydroalcoholic extract of Equisetum arvense.
    Author: Dos Santos JG, Blanco MM, Do Monte FH, Russi M, Lanziotti VM, Leal LK, Cunha GM.
    Journal: Fitoterapia; 2005 Sep; 76(6):508-13. PubMed ID: 15972249.
    Abstract:
    The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rota-rod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. In the pentylenetetrazole-seizure, it increased the first convulsion latency, diminished the severity of convulsions, reduced the percentage of animals which developed convulsion (50% and 25%) and protected animals from death. On the contrary, in the elevated plus maze, the doses 50, 100 and 150 mg/kg did not affect the evaluated parameters. Thus, HAE presented anticonvulsant and sedative effects. Phytochemical analysis detected the presence of tannins, saponins, sterols and flavonoids.
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