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  • Title: Induction method of tyrosine kinase A-mediated cell death in rat pheochromocytoma.
    Author: Ahn JY, Kang L, Kim HJ, Kang H, Kim SH, Kim JY, Kim SK, Wang KC, Cho BK, Lee KW, Roh JK, Kim M.
    Journal: Biotechnol Lett; 2005 Apr; 27(8):583-7. PubMed ID: 15973493.
    Abstract:
    Nerve Growth Factor (NGF) is a neurotrophic factor that prevents apoptosis in neuronal progenitor cells. In rat pheochromocytoma (PC12) cells, tyrosine kinase A receptor (TrkA) mediates neurotrophic or protective effects, while p75 neurotrophin receptor (p75NTR) functions as a death receptor. We have determined whether TrkA mediates any cytotoxic effect. Following serum deprivation, TrkA expression increased 2.2-fold and apoptosis began with expression of Bax proapoptotic protein. Application of NGF halved cell viability but this was reversed by K252a, the TrkA inhibitor. These results confirmed the paradoxical cytotoxic effect of neurotrophic NGF via TrkA in PC12 cells following serum deprivation.
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