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  • Title: Heparin-induced thrombocytopenia and the use of r-hirudin during cardiopulmonary bypass.
    Author: Manikappa S, Benfield K, Gan TE, Butler J, Malan E, Tran HA, Tucker A.
    Journal: Anaesth Intensive Care; 2005 Jun; 33(3):388-92. PubMed ID: 15973924.
    Abstract:
    We report the successful use of r-hirudin (lepirudin) for cardiopulmonary bypass in a 67-year-old man who developed heparin-induced thrombocytopenia type II during heparin treatment of an extensive deep venous thrombosis. Lepirudin was monitored by the modified ecarin clotting time in a "mobile laboratory" set up next to the cardiac theatre, aiming for lepirudin levels of 3.5 to 4.5 microg/ml during bypass.
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