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  • Title: Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
    Author: Dymock BW, Barril X, Brough PA, Cansfield JE, Massey A, McDonald E, Hubbard RE, Surgenor A, Roughley SD, Webb P, Workman P, Wright L, Drysdale MJ.
    Journal: J Med Chem; 2005 Jun 30; 48(13):4212-5. PubMed ID: 15974572.
    Abstract:
    The crystal structure of a previously reported screening hit 1 (CCT018159) bound to the N terminal domain of molecular chaperone Hsp90 has been used to design 5-amide analogues. These exhibit enhanced potency against the target in binding and functional assays with accompanying appropriate cellular pharmacodynamic changes. Compound 11 (VER-49009) compares favorably with the clinically evaluated 17-AAG.
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