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  • Title: Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis.
    Author: Appendino G, Aviello G, Ballero M, Borrelli F, Fattorusso E, Petrucci F, Santelia FU, Taglialatela-Scafati O.
    Journal: J Nat Prod; 2005 Jun; 68(6):853-7. PubMed ID: 15974607.
    Abstract:
    Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.
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