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  • Title: Neoflavonoids and related constituents from Nepalese propolis and their nitric oxide production inhibitory activity.
    Author: Awale S, Shrestha SP, Tezuka Y, Ueda JY, Matsushige K, Kadota S.
    Journal: J Nat Prod; 2005 Jun; 68(6):858-64. PubMed ID: 15974608.
    Abstract:
    A methanolic extract of Nepalese propolis yielded 10 new open-chain neoflavonoids (1-10), a new chalcone (11), and eight previously reported compounds (12-19). Their structures were determined on the basis of spectroscopic data and chemical conversion. The isolated compounds other than 5, 8, and 16 showed dose-dependent inhibitory activities on nitric oxide production in lipopolysaccharide-activated macrophage-like J774.1 cells and were more active than a positive control, N(G)-monomethyl-L-arginine (IC(50), 27.1 microM). The most potent activities, of 6 and 7 (IC(50), 0.5 microM), were greater than another positive control, caffeic acid phenethyl ester (IC(50), 4.8 microM).
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