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  • Title: Polyoxygenated steroids from the gorgonian Isis hippuris.
    Author: Chao CH, Huang LF, Yang YL, Su JH, Wang GH, Chiang MY, Wu YC, Dai CF, Sheu JH.
    Journal: J Nat Prod; 2005 Jun; 68(6):880-5. PubMed ID: 15974612.
    Abstract:
    Eleven new hippuristanols (1-4, 7-9, and 11-14), along with eight known metabolites (5, 6, 10, and 15-19), have been isolated from the gorgonian coral Isis hippuris. Single-crystal X-ray diffraction analyses supported the structure elucidation of known steroids 5 and 10. The absolute structures of hippuristanols were established by application of modified Mosher's method on 19. Compounds 14-19 have been found to exhibit significant cytotoxicity against several cancer cell lines.
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