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  • Title: [Mechanism of action of T cell factors regulating antibody formation].
    Author: Rabourdin-Combe C, Yagello M, Fridman WH.
    Journal: C R Seances Soc Biol Fil; 1979; 173(2):221-30. PubMed ID: 159750.
    Abstract:
    While the induction of antibody synthesis depends on antigen specific T cell factors, its magnitude is under control of non antigen specific T cell factors. In this respect, TRF ("T cell Replacing Factor") amplifies antibody responses while IBF ("Immunoglobulin Binding Factor") acts as a suppressor factor. Using cultures of spleen cells from nude mice, we show that both factors act sequentially, influencing the final differenciation of B cells to antibody producing cells. We have no evidence of direct interaction between TRF and IBF.
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