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  • Title: New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease?
    Author: Maillet M, Robert SJ, Lezoualc'h F.
    Journal: Curr Alzheimer Res; 2004 May; 1(2):79-85. PubMed ID: 15975071.
    Abstract:
    The serotonin 5-HT4 receptor mediates many physiological effects in the central nervous system. The recent molecular identification of 5-HT4 receptors and the development of selective 5-HT4 receptor ligands have led to many important new insights into the signalling pathways and the physiological roles of these G protein-coupled-receptors in neurones. With respect to neurodegenerative disorders, it is suggested that 5-HT4 agonists may represent a new avenue for the treatment of Alzheimer's disease. This mini-review will focus on recent in vitro and in vivo pharmacological and biochemical studies showing the involvement of 5-HT4 receptors in cognitive processes and the amyloid precursor protein processing. The potential use of 5-HT4 agonists for the treatment of AD will be discussed.
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