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  • Title: Nature's protection racket.
    Author: Micklefield J.
    Journal: Chem Biol; 2005 Jun; 12(6):611-3. PubMed ID: 15975504.
    Abstract:
    (2S)-4-amino-2-hydroxybutyrate (AHBA) is a side chain that is important for the antibiotic activities of aminoglycosides. The elucidation of the biosynthetic pathway to AHBA, by Spencer et al. in this issue of Chemistry & Biology [1], reveals several surprises and will facilitate biosynthetic engineering of new improved aminoglycoside antibiotics.
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