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  • Title: Osteomalacia due to chemotherapy-induced Fanconi syndrome in an adult patient.
    Author: Duck L, Devogelaer JP, Persu A, Berlière M, Caussin E, Baurain JF, Machiels JP.
    Journal: Gynecol Oncol; 2005 Aug; 98(2):329-31. PubMed ID: 15975640.
    Abstract:
    BACKGROUND: Chemotherapy-induced Fanconi syndrome is a dangerous condition that could lead to severe electrolyte disturbances and rarely to osteomalacia. CASE: A patient treated with ifosfamide for a metastatic cervix squamous-cell carcinoma was admitted for diffuse, symmetric bilateral pain in bones and articulations. The diagnosis work-up revealed that she suffered from osteomalacia due to a chemotherapy-induced Fanconi syndrome. The patient recovered completely with oral calcitriol supplements. CONCLUSIONS: This very rare chemotherapy-complication suggests that detection of potential tubular dysfunction, by regular serum electrolyte monitoring of patients receiving ifosfamide, may be a reasonable approach to diagnose early chemotherapy-induced Fanconi syndrome, even in adults.
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