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  • Title: [Changes of somatostatin (SS) in stomach and duodenum of rats after +Gz exposure].
    Author: Zhong XJ, Wu ZJ, Sun YP, Xu G, Xu KG, Tian GQ.
    Journal: Space Med Med Eng (Beijing); 2005 Apr; 18(2):148-50. PubMed ID: 15977397.
    Abstract:
    OBJECTIVE: To study effects of +Gz exposure on the change of somatostatin (SS) in stomach and duodenum of rats. METHOD: Forty male Wistar rats were randomly divided into +1 Gz control group, +5 Gz x 5 min group, +10 Gz x 5 min group and repeated exposure [(+5 Gz x 2 min) + (+10 Gz x 2 min) + (+5 Gz x 2 min)] group. After +Gz exposure, the rats in each group were anesthesized by aether, and gastric and duodenal mucosa were taken immediately. Levels of SS were assayed using radioimmunoassay (RIA) methods. RESULTS: Gastric and duodenal mucosa of the control group and +5 Gz group were intact and smooth. Under naked eye and light microscope, scattered hemorrhagic spoto, small ulcers, submucosal hyperemia, and erosion of mucosa were found in gastric antrum and duodenum in +10 Gz group rats. Diffuse hyperemia, erosion and small ulcers were found in mucosa of gastric fundus, gastric antrum and duodenum of repeated exposure group. Exposure to +Gz can increase somatostatin content in gastric antrum and duodenum (P<0.01). CONCLUSION: Increase of SS content may play an important role in the prevention of pathogenesis of stomach and duodenum after +G exposure.
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