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  • Title: [Conformational and intermolecular interactions of proteins in amyloidosis].
    Author: Mal'tsev AV, Kaminskiĭ IuG, Il'iasov FE, Rozanova NA, Fediukin VS, Baĭramov VM.
    Journal: Biofizika; 2005; 50(3):470-4. PubMed ID: 15977837.
    Abstract:
    A conception on amyloidosis as a key factor of neuronal death in neurodegenerative diseases is stated. Experimental evidence is presented that amyloidosis is caused by alterations in the activity of a number of enzymes as well as conformational changes in pathogenic proteins. Arguments for amyloidosis as the universal biological mechanism of specific elimination of neurons showing changed metabolic and physiological status of cell differentiation are adduced. The final pattern of cell death seems to differ cardinally from that in both apoptosis and necrosis.
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