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  • Title: Development of a polymorphic strain of Plasmodium vivax in monkeys.
    Author: Collins WE, Sattabongkot J, Wirtz RA, Skinner JC, Broderson JR, Millet PG, Morris CL, Richardson BB, Sullivan J, Filipski VK.
    Journal: J Parasitol; 1992 Jun; 78(3):485-91. PubMed ID: 1597793.
    Abstract:
    A strain of Plasmodium vivax from Thailand with a polymorphic repeat unit of the circumsporozoite protein was established in Saimiri sciureus boliviensis and 3 species of Aotus monkeys. All 11 attempts to transmit infection via sporozoite inoculation, 4 times to splenectomized S. sciureus boliviensis, 2 times to splenectomized Aotus nancymai, and 5 times to intact Saimiri monkeys, were successful. Anopheles freeborni, Anopheles stephensi, Anopheles dirus, and Anopheles gambiae mosquitoes were infected by feeding on parasitemic blood from a chimpanzee and an Aotus azarae boliviensis monkey. Our results indicate that this strain may be useful in antisporozoite vaccine trials.
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