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  • Title: Design and synthesis of low molecular weight compounds with complement inhibition activity.
    Author: Master HE, Khan SI, Poojari KA.
    Journal: Bioorg Med Chem; 2005 Aug 15; 13(16):4891-9. PubMed ID: 15978815.
    Abstract:
    An attempt was made to synthesize a series of non-cytotoxic low molecular weight compounds of varying substitutions and functionalities having pharmacophore activity like carbonyl compounds, carboxylic acid and bioisosteres like tetrazole and phenyl acrylic acid. The in vitro assay of these analogues for the inhibition of complement activity revealed significant inhibitory activity for varying substituents and, particularly, for bioisosteres, that is, tetrazole and phenyl acrylic acid derivatives.
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