These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Localization and altered expression of AKR1C family members in human ovarian tissues.
    Author: Ji Q, Aoyama C, Chen PK, Stolz A, Liu P.
    Journal: Mol Cell Probes; 2005 Aug; 19(4):261-6. PubMed ID: 15979276.
    Abstract:
    Relative expression of AKR1C family members and 5alphaR1 were determined using gene specific quantitative real-time PCR method. Both ARK1C1 and AKR1C2 were found significantly reduced in ovarian tumor tissues compared to ovarian normal tissues. In contrast, AKR1C3 and 5alphaR1 were kept the same transcriptional levels between ovarian tumor tissues and ovarian normal tissues. Immunohistochemical staining indicates that AKR1C1 shares the same localization with AKR1C3. Loss of ARK1C1 and AKR1C2 in ovarian cancerous tissues may enhance progesterone signaling in ovary itself by decreasing the ability of progesterone metabolism.
    [Abstract] [Full Text] [Related] [New Search]