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  • Title: Association between consumption of beer, wine, and liquor and plasma concentration of high-sensitivity C-reactive protein in women aged 39 to 89 years.
    Author: Levitan EB, Ridker PM, Manson JE, Stampfer MJ, Buring JE, Cook NR, Liu S.
    Journal: Am J Cardiol; 2005 Jul 01; 96(1):83-8. PubMed ID: 15979440.
    Abstract:
    Although cross-sectional studies have shown an inverse or U-shaped relation between alcohol consumption and plasma concentration of high-sensitivity C-reactive protein (hs-CRP), the associations between specific types of alcoholic beverages--beer, wine, and liquor--and hs-CRP concentrations are less clear. Plasma concentrations of hs-CRP were measured in 11,815 participants in the Women's Health Study who had never used postmenopausal hormones. Alcohol intake was measured using a semiquantitative food-frequency questionnaire. Alcohol consumption had an inverse association with geometric mean hs-CRP concentrations (nondrinkers 1.43 mg/L, 0.1 to 6 g alcohol/day 1.37 mg/L, 6.1 to 12 g alcohol/day 1.29 mg/L, >12 g alcohol/day 1.28 mg/L, p for trend = 0.003). In age-adjusted analyses, beverage preference was a significant predictor of geometric mean hs-CRP concentration. However, after adjustment for body mass index (BMI), beer drinkers who consumed 6.1 to 12 g alcohol/day had a geometric mean hs-CRP concentration of 1.03 mg/L, wine drinkers 1.09 mg/L, liquor drinkers 1.28 mg/L, and combination drinkers 1.09 mg/L (p = 0.43). The association between alcohol and hs-CRP concentration appears to be mediated primarily by ethanol and was independent of the type of alcoholic beverage consumed once BMI was taken into account.
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