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  • Title: Synthesis and antimalarial activities of some furoxan sulfones and related furazans.
    Author: Galli U, Lazzarato L, Bertinaria M, Sorba G, Gasco A, Parapini S, Taramelli D.
    Journal: Eur J Med Chem; 2005 Dec; 40(12):1335-40. PubMed ID: 15979766.
    Abstract:
    Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquine-sensitive D10 and the chloroquine-resistant W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the -SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the microM range, possibly related in part to their ability to release NO.
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