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  • Title: Leukocyte migration: dismantling inhibition.
    Author: Brown EJ.
    Journal: Trends Cell Biol; 2005 Aug; 15(8):393-5. PubMed ID: 15982887.
    Abstract:
    A new study demonstrates that the Src-family kinases Fgr and Hck inhibit chemokine signaling in polymorphonuclear leukocytes and dendritic cells by phosphorylation of PIR-B, an inhibitory receptor expressed on leukocytes. In resting cells, PIR-B phosphorylation is constitutive but is decreased transiently by addition of chemokines. In Fgr/Hck-deficient cells, constitutive PIR-B phosphorylation is markedly decreased. These Src-family kinases have a novel role in tonic inhibition of cell activation that must be overcome to allow the phenotypic effects of chemokine signaling through G-protein-coupled receptor ligands.
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