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  • Title: Age-specific antibody to hepatitis E virus has remained constant during the past 20 years in Japan.
    Author: Tanaka E, Matsumoto A, Takeda N, Li TC, Umemura T, Yoshizawa K, Miyakawa Y, Miyamura T, Kiyosawa K.
    Journal: J Viral Hepat; 2005 Jul; 12(4):439-42. PubMed ID: 15985017.
    Abstract:
    We investigated the presence of antibodies to hepatitis E virus (anti-HEV) and hepatitis A virus (anti-HAV) by enzyme immunoassays in sera from 1015 individuals collected in 1974, 1984 and 1994. Age-specific profiles of anti-HEV remained unchanged with a peak at 40-49 years, while those of anti-HAV started to increase in individuals aged 20-29 years in 1974, 30-39 years in 1984 and 40-49 years in 1994. These results suggest that a silent HEV infection has been taking place in the last 20 years or so in Japan, while HAV infection has been terminated at least since 1974.
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